个人简介

哥本哈根大学博士后，海南省D类高层次人才，主要研究领域为热带传统食品生物制造，具体包括1）：益生菌及后生元产品开发及其抗氧化、抗炎和抗肿瘤等营养与功能评价；2）植物化学物的肠道吸收、代谢的构效关系及作用机制；3）：热带作物（如胡椒、咖啡等）新产品开发、活性成分鉴定及活性机制研究。近年来以第一作者或通讯作者身份发表 SCI论文13篇，封面文章1篇，受邀担任Frontiers in Nutrition和Science & Technology NEXUS杂志副主编，主持国家自然科学基金青年基金1项、海南省自然科学基金1项、海口市科技计划项目1项和横向课题2项；参与多项国家自然科学基金面上项目等国家级项目，以及丹麦食品、农业与水产部，丹麦乳品研究基金会等项目多项。

教育背景

2012.9-2018.6： 华中农业大学，食品科学与技术学院，食品科学专业，工学博士  
2008.9-2012.6： 华中农业大学，食品科学与技术学院，食品质量与安全专业，理学学士

工作经历

2021.06-至今   古天乐ok138太阳成集团官网，古天乐ok138太阳成集团官网，副教授
2019.01-2021.03 哥本哈根大学，食品科学系，博士后

科研项目

1. 国家自然科学基金青年基金项目，基于P-糖蛋白抑制作用促进二氢槲皮素肠吸收的分子机制（32302002），2024-2026，30万，在研，主持；
2. 古天乐ok138太阳成集团官网其他类高层次人才启动经费，柑橘类黄酮协同抑制肠道外排蛋白与相代谢酶偶联作用的分子机制（RZ2200001257），2021-2026，10万，在研，主持；
3. 海南省自然科学基金青年基金，椰子水品质评价体系的构建（322QN253），2022至2025，6万，结题，主持；
4. 深圳保时健生物工程有限公司技术开发合同，功能性益生菌筛选和开发，2024-2025，25万，在研，主持；
5. 海南省壹升实业有限公司技术开发合同，益智红茶产品开发与品质评价（HD-KYH-2021289），2021-2024，10万，结题，主持；
6. 海口市科技计划项目，生椰拿铁产品制备关键研究与产品开发（2022-014），2022-2025，60万，结题，参与；
7. 海南省食品营养与功能食品开放课题（KF202201）, 2023-2024，2万，结题， 主持；
8. 丹麦乳品研究基金会资助项目“UHT treatment and storage effects on the biological quality of liquid infant formulas超高温瞬时灭菌处理与贮藏对液态婴儿配方奶的生物活性影响”，2020-2023，200万，结题，参与；
9. 丹麦食品、农业与水产部、欧洲最大乳品企业爱氏晨曦Arla与哥本哈根大学食品系合作项目“Tailored processing of bioactive ingredients for high-end infant formula高端婴儿配方奶的活性配料的定制加工工艺”，2019-2024，1140万，结题，参与。

文章著作

1. Zhang Z#, Fang Y#, He Y#, Farag M A, Zeng M, Sun Y, Peng S, Jiang S, Zhang X, Chen K, Xu M, Han Z, Zhang J. Bifidobacterium animalis Probio-M8 improves sarcopenia physical performance by mitigating creatine restrictions imposed by microbial metabolites. NPJ Biofilms Microbiomes. 2024 Dec 5;10(1):144.
2. Ye Y#, Fang Y#, Engholm-Keller K, Bechshøft M R, Chatterton D E W, Sangild P T, Nguyen D N, Bering S B, Lund M N. Protein digestibility and anti-inflammatory activity of processed whey protein ingredients for infant formula. Journal of Agricultural and Food Chemistry. 2025, https://doi.org/10.1021/acs.jafc.4c08785.
3. Peng S, Wang J, Farag M A, Salah M, Liu L, Fang Y*, Zhang W*. Impact of refining on phytochemicals and anti-inflammatory activity of papaya (Carica papaya L.) seed oil in LPS-stimulated THP-1 cells. Food Chemistry. 2024. 459, 140299.
4. Song H, Xue H, Zhang Z, Wang J, Li A, Zhang J, Luo P, Zhan M, Zhou X, Chen L, and Fang Y*. Amelioration of Type 2 Diabetes Using Four Strains of Lactobacillus Probiotics: Effects on Gut Microbiota Reconstitution-Mediated Regulation of Glucose Homeostasis, Inflammation, and Oxidative Stress in Mice. Journal of Agricultural and Food Chemistry. 2023, 71(51), 20801-20814. (封面文章)
5. Guo Y, Jia Z, Wan L, Cao J, Fang Y*, Zhang W*. Effects of refining process on Camellia vietnamensis oil: Phytochemical composition, antioxidant capacity, and anti-inflammatory activity in THP-1 macrophages. Food Bioscience. 2023, 52, 102440.
6. Zhang W, Chen Y, Yun Y, Li C, Fang Y*, Zhang W*. Discrimination and characterization of different coconut water (CW) by their phenolic composition and volatile organic compounds (VOCs) using LC-MS/MS, HS-SPME-GC-MS, and HS-GC-IMS. Journal of Food Science. 2023, 1-15.
7. Fang Y, Cao W, Xia M, Pan S, Xu X. Transport and interactions of co-incubated bi-functional flavonoids through inhibiting the function of P-glycoprotein (P-gp) using KB/Multidrug-resistant (MDR) cells and rat everted gut sacs. Journal of Agricultural and Food Chemistry. 2022, 70, 1923-1933.
8. Fang Y, Liang F, Xia M, Cao W, Pan S, Wu T, Xu X. Structure-activity relationship and mechanism of flavonoids on the inhibitory activity of P-glycoprotein (P-gp)-mediated transport of rhodamine123 and daunorubicin in P-gp overexpressed human mouth epidermal carcinoma (KB/MDR) cells. Food and Chemical Toxicology. 2021, 155, 112381.
9. Fang Y, Cao W, Liang F, Xia M, Pan S, Xu X. Structure affinity relationship and docking studies of flavonoids as substrates of multidrug-resistant associated protein 2 (MRP2) in MDCK/MRP2 cells. Food Chemistry, 2019, 291: 101-109.
10. Fang Y, Xia M, Liang F, Cao W, Pan S, Xu X. Establishment and use of human mouth epidermal carcinoma (KB) cells overexpressing P-glycoprotein to characterize structure requirements for flavonoids transported by the efflux transporter. Journal of Agricultural and Food Chemistry. 2019, 67, 8, 2350-2360.
11. Fang Y, Liang F, Liu K, Qaiser S, Pan S, Xu X. Structure characteristics for intestinal uptake of flavonoids in Caco-2 cells. Food Research International. 2018, 106: 353-360.  
12. Fang Y, Cao W, Xia M, Pan S, Xu X. Study of structure and permeability relationship of flavonoids in Caco-2 cells. Nutrients. 2017, 9(12): 1301.  
13. Fang Y, Lu Y, Zang X, Wu T, Qi X, Pan S, Xu X. 3D-QSAR and docking studies of flavonoids as potent Escherichia coli inhibitors. Scientific Reports. 2016, 6, 23634.
14. 方雅静，何梦影，潘思轶，徐晓云. 类黄酮构效关系研究进展. 华中农业大学学报. 2015, 34(6): 146-154.
15. Liang F, Fang Y, Cao W, Zhang Z, Pan S, Xu X. Attenuation of tert-Butyl Hydroperoxide (t-BHP)-induced oxidative damage in HepG2 cells by tangeretin: relevance of the Nrf2-ARE and MAPK signaling pathways. Journal of Agricultural and Food Chemistry, 2018, 66(25): 6317-6325.  
16. Xia M, Fang Y, Cao W, Liang F, Pan S, Xu X. Quantitative Structure–Activity Relationships for the Flavonoid-Mediated Inhibition of P-Glycoprotein in KB/MDR1 Cells. Molecules. 2019; 24(9): 1661.  
17. Cao W, Fang Y, Wu T, Liang F, Cheng Y, Pan S, Xu X. Insights from multispectral and molecular docking investigation on the xanthine oxidase inhibition by 1,4-dicaffeoylquinic acid. Journal of Molecular Structure, 2020, 1219: 128475.  
18. Ye Y, Engholm-Keller K, Fang Y, Nielsen CF, Jordà A, Lund MN, Chatterton DEW. UHT treatment and storage of liquid infant formula affects protein digestion and release of bioactive peptides. Food & Function, 2022, 13, 344-355.
19. Liang F, Cao W, Huang Y, Fang Y, Pan S, Xu X. Isoflavone biochanin A, a novel nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element activator, protects against oxidative damage in HepG2 cells. BioFactors. 2019; 1-12.    
20. Cheng Y, Wu T, Tang S, Liang F, Fang Y, Cao W, Pan S, Xu X. Fermented blueberry pomace ameliorates intestinal barrier function through the NF-κB-MLCK signaling pathway in high-fat diet mice.  Food & Function, 2020, 11, 3167.  
21. 曹伟伟，吴婷，方雅静，程玉鑫，潘思轶，徐晓云. 藜蒿叶中1,4-双咖啡酰奎宁酸的鉴定及双咖啡酰奎宁酸类化合物体外抑制黄嘌呤氧化酶和抑制尿酸钠诱导IL-1β的构-效关系[J]. 中国食品学报，2020，20(2)：1-8.

获奖

无

专利

无

承担教学

（1）本科生课程：《食品生物化学》，《新生入学教育与导学》；（2）研究生课程：《食品微生物学进展》，国际课程《Advanced Food Chemistry》，国际课程《Protein Modifications in Food Systems: Chemistry and Analysis》

研究生培养

目前在读博士研究生1人、硕士研究生5人，毕业研究生1人，欢迎对热带传统食品领域感兴趣的同学报考我的研究生。